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Retail - Rental Express - Error Saving Printer Options

Most likely this is a permissions issue which most commonly happens on a 64bit maching with Windows 7 or newer operating system

As administrator on that PC 
run regedit
go to HKEY_LOCAL_MACHINE/SOFTWARE/WOW6432Node/AXS   
right click and go to permissions
click on the users(that will be running app) and give them full control
click advanced and check the Replace all child object permissions etc... and press ok
Then press ok on the permission screen

That will allow the users to save the printer setup.